Champions

[Jonathan Meer]

Honestly, I'm guessing you're not doing his combo correctly.

Q>W>Q>E>Q>R>Q

At the end of that, both Q and W should be up at about the same time. Between spell casts you just walk along whatever path the enemy will be taking so they don't get out of spell range. One of the developers described Ryze as a "spell machine gun" and that's exactly what he is.

Yeah, that's the combo I do (though I switch over to Q>E>Q>W..., if I know I won't need the cage). Usually seems, though, that I either can't go through an entire combo for mana reasons (early-game) or am playing against tons of magic resist (late-game).